Universität Zürich · Education
Postdoctoral Researcher – Next-Generation CAR Immune Cell Therapies Against Malignant Brain Tumors (ERC-funded),
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Specific project goals:
- Generate CAR immune cell communities, comprising mixtures of engineered T cells, NK cells, monocytes, and additional cell types, using sophisticated in vitro and in vivo engineering platforms.
- Identify co-factors that boost CAR immune cell function using cutting-edge screening platforms.
- Investigate anti-tumor activity and immune-cancer-cell environmental crosstalk in vitro and in vivo using sophisticated disease models (organoids, slice cultures, patient-derived samples, mouse models) and modern technologies including flow cytometry, multiplexed imaging, spatial transcriptomics/proteomics and single-cell profiling.
- Analyze patient samples from an accompanying clinical trial evaluating CAR immune cell communities.
- Intellectual curiosity, creativity and a proactive approach to problem-solving
- Motivation to contribute to a project with direct patient impact
- PhD in immunology, computational immunology, cell/molecular/cancer biology, bioengineering, biomedical sciences, or a related field
- Experience with immune cell engineering, cellular immunotherapy, and/or advanced in vitro/in vivo disease models is highly desirable
- Familiarity with single-cell and/or spatial technologies is a plus
- Strong publication record demonstrating scientific productivity
- Excellent communication skills and the ability to thrive in an interdisciplinary team